I have Kubuntu 22.04.1 LTS. I've just attached speakers and they weren't working (I'm using the virtual output to have output on both headphones [attached to front panel] and speakers [attached to rear]), so I've found that my system has alsa as part of pulseaudio. Moreover, alsamixer can re-enable the sound -- by selecting my sound card, then moving across to the right, then toggling the "auto-mut" (sic.) setting to "Disabled" -- but this enabling doesn't survive reboot; it's the problem solved here in 2012 and unsolved here in 2017.
Pulseaudio controls, and System Settings > Audio (in Plasma desktop) don't appear to have this setting. So what's the current way to fix it? I thought that alsa was deprecated when pulseaudio became mature enough, so I'm wondering whether I need to remove alsa completely to have my system operate sound correctly; maybe it's interfering which would explain why that setting is not in the KDE/Plasma system settings nor accessible from the pulseaudio volume controls?? A solution uses amixer, is that still the best way (but modified for rc-local.service)?