Much of the time, my laptop (Windows 7, Lenovo ThinkPad) will be using the expected ~50-70% of RAM, only going higher when I, say, play a game or load a bunch of images. But sometimes it's randomly using 90% for no apparent reason. Following a string of Google's recommendations, I ended up with poolmon. It revealed that there were at least six culprits working together in a nefarious plot to moderately inconvenience me.
They were tagged File, IoNM, NtfI, NtfE, and two had tags starting with NtF. "File" and one of the "Ntf"s were taking up more than a GB each when I first opened up poolmon, and all of the other ones near the top of the "most bytes" ranking. Google says all the "ntf"s are related to NTFS, which sounds important, so killing ntfs.sys sounds like a bad idea.
In summary: NTFS occasionally does something funky that takes up >2GB RAM and then gradually fades away. What can I do/not do in order to stop this from happening?
