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Spotify and Skype Business sound is breaking badly on Lenovo Thinkpad T430 laptop anytime when there is significant CPU load (25% or more). For example browsing files or running Eclipse searches or indexing cause bad stutter. Windows 7 64 bit professional. I have had this problem for a few months and have been desperately looking for help. How can I fix this?

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I finally found a fix for this from: Mouse is unresponsive when the computer is busy

VeganCaramels answer worked:

Start > Run > msconfig > click Boot tab > click Advanced Options > make sure "Number of processors" shows the number of cores your processor actually has (change it to the correct number if it's wrong)

I have Intel i5-520M dual core CPU so I set the "Number of processor" to 2. The problems disappeared immediately after reboot. My computer also speeded up significantly, for example Eclipse search is now at least 2-3x faster for same codebase.

I suspect this has got to do with some bug in Hyperthreading support, I have enabled it in BIOS for Virtualbox purposes.