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Random directories in c:\ that I cannot delete

We have just set up a new windows 2008 R2 server with three separate raid arrays as drives C:, F: and I:. After installing all the windows updates and Trend Micro anti virus, we see at the root of our F: volume a folder named "c323e2a243c313f307e247fd" containing only an empty folder named "Sandbox". It has unique security applied

Where might it have come from? And what if we delete it?

Mike Schenk
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